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Tryptophan supplements fell out of favor when a contaminated batch from Japan caused thousands to fall ill in the 1980s.

Tryptophan more readily enters the brain, but 5-HTP requires one less step to convert into serotonin.Serotonin supplements like specific amino acids, vitamins, minerals and herbs increase serotonin levels helping depression and other brain-related disorders.Serotonin is a neurotransmitter that plays a large role in mood, learning, appetite control, and sleep.But since protein blocks serotonin synthesis, eating a meal containing protein will actually cause both tryptophan and serotonin levels drop.However, tryptophan supplements can increase brain serotonin even though eating foods containing tryptophan does not (5).

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